Research funded by:

2026
  • Savage D, Hu Jiafen, Burgener AD, Raouf A and Murooka TT. Cell-mediated immunity against human papillomavirus infection: from viral clearance to oncogenesis. Viruses. 2026. In press.
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  • Mou Zhirong, Zayats R, Salako E, Ikeogu N, Onwah S, Liu D, Hamana H, Kishi H, Tan D, Leung C, Arsenio J, Murooka TT*, Uzonna JE*. Persistent antigen is essential for sustaining Leishmania major-specific memory CD4 T cells and long-term immunity. Science Advances. Vol 12, Issue 10. *Co-corresponding authors
 
  • Brendle S, Li J, Lu S, Schell TD, Kozak M, Walter V, Shearer D, Place J, Balogh K, Casanova JL, Christensen N, Burgener AD, Murooka TT, Zhu Y, Béziat V, Hu J. CD28-deficient mice are vulnerable to mouse papillomavirus MmuPV1 infection of the skin and mucosae. PLoS Pathog. 2026 Mar 10;22(3):e1013968. doi: 10.1371/journal.ppat.1013968. eCollection 2026 Mar.
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  • Pizzagalli DU, Carrillo-Barberà P, Bansal H, Palladino E, Ceni K, Thelen B, Pulfer A, Moscatello E, Fiamma Cabini R, Textor J, M N Wortel I; Immunemap Consortium; Krause R, Fernandez Gonzalez S. Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap. EMBO J. 2026 Jan;45(1):334-348. doi: 10.1038/s44318-025-00629-4. Epub 2025 Nov 20.

2025
  • Nuhu F, Costa-Fujishima M, Gavino C, Ssemaganda A, Verdipanah M, Jahan N, Murooka TT, McKinnon LR. Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge. Mucosal Immunol. 2025 Dec;18(6):1298-1312. doi: 10.1016/j.mucimm.2025.08.006. Epub 2025 Aug 21.
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  • ​Lithium attenuates HIV-1 latency reversal in an autophagy-independent way.Abdalla AL, Guajardo-Contreras G, Chau BA, Niu M, Murooka T, Mouland AJ. iScience. 2025 Nov 19;28(12):114085. doi: 10.1016/j.isci.2025.114085. eCollection 2025 Dec 19.

2024
  • Bellini N, Ye C, Ajibola O, Murooka TT, Lodge R, Cohen ÉA. Downregulation of miRNA-26a by HIV-1 Enhances CD59 Expression and Packaging, Impacting Virus Susceptibility to Antibody-Dependent Complement-Mediated Lysis. Viruses. 2024 Jul 4;16(7):1076. doi: 10.3390/v16071076.
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  • Atkins HM, Uslu AA, Li JJ, Shearer DA, Brendle SA, Han C, Kozak M, Lopez P, Nayar D, Balogh KK, Abendroth C. Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening. mBio. 2024 Aug 14;15(8):e01420-24.
 
  • Guizar P, Abdalla AL, Monette A, Davis K, Caballero RE, Niu M, Liu X, Ajibola O, Murooka TT, Liang C, Mouland AJ. An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity. iScience. 2024 May 27;27(6):110131. doi: 10.1016/j.isci.2024.110131.

  • Transformer-based spatial-temporal detection of apoptotic cell death in live-cell imaging.
    Pulfer A, Pizzagalli DU, Gagliardi PA, Hinderling L, Lopez P, Zayats R, Carrillo-Barberà P, Antonello P, Palomino-Segura M, Grädel B, Nicolai M, Giusti A, Thelen M, Gambardella LM, Murooka TT, Pertz O, Krause R, Gonzalez SF. Elife. 2024 Mar 18;12:RP90502. doi: 10.7554/eLife.90502.                                                                                                                                                 
2023
  • Zayats R, Mou Z, Yazdanpanah A, Gupta G, Lopez P, Nayar D, Koh WH, Uzonna JE*, Murooka TT*. Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence. Nature Communications. 2023 Dec 19;14(1):8449. *Co-corresponding authors
 
  • Ikeogu N, Ajibola O, Zayats R, Murooka TT. Identifying physiological tissue niches that support the HIV reservoir in T cells. mBio. 2023 Oct 31;14(5):e0205323. doi: 10.1128/mbio.02053-23. Epub 2023 Sep 25.     
                                                                                                                                                  
  • ​Costa-Fujishima M, Yazdanpanah A, Horne S, Lamont A, Lopez P, Zuend CF, Birse K, Taverner M, Greenslade R, Abou M, Noel-Romas L. Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract. Mucosal Immunology. 2023 Jun 1;16(3):341-56.                                                                               
2022

  • Bellini N, Lodge R, Pham TNQ, Jain J, Murooka TT, Herschhorn A, Bernard NF, Routy JP, Tremblay CL, Cohen ÉA. MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells. iScience. 2022 Sep 28;25(10):105234. doi: 10.1016/j.isci.2022.105234. eCollection 2022 Oct 21. 
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  • Zayats R, Murooka TT, McKinnon LR. HPV and the Risk of HIV Acquisition in Women. Front Cell. Infect. Microbiol. 2022 Feb 10;12:814948.
 
  • Lopez P, Ajibola O, Pagliuzza A, Zayats R, Koh WH, Herschhorn A, Chomont N, Murooka TT.T cell migration potentiates HIV infection by enhancing viral fusion and integration. Cell Reports. 2022 Feb 22;38(8):110406.


2021
  • Brendle S, Li JJ, Cladel NM, Shearer DA, Budgeon LR, Balogh KK, Atkins H, Costa-Fujishima M, Lopez P, Christensen ND, Doorbar J, Murooka TT, Hu J. Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues. Viruses. 2021 Sep 14;13(9):1824.
 
  • Hosoya T, Cordelia D, Michael BD, Miyabe C, Nagai J, Murooka TT, Miyabe Y. Editorial: Targeting the Chemoattractant System in Inflammation. Front Pharmacol. 2021 Aug 16;12:744290.
 
  • Zayats R, Uzonna JE, Murooka TT. Visualizing the In Vivo Dynamics of Anti-Leishmania Immunity: Discoveries and Challenges. Front Immunol. 2021 May 19;12:671582.
 
  • Ikeogu NM, Edechi CA, Akaluka GN, Feiz-Barazandeh A, Zayats RR, Salako ES, Onwah SS, Onyilagha C, Jia P, Mou Z, Shan L, Murooka TT, Gounni AS, Uzonna JE. Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4+ Th1 Cell Response (2021). J Immunol. 2021 Feb 1;206(3):588-598.


2020
  • Koh WH*, Zayats R*, Lopez P, Murooka TT. Visualizing Cellular Dynamics and Protein Localization in 3D Collagen (2020). STAR Protoc. Dec 8;1(3):100203.      *co-first authorship
 
  • Gupta G, Mou Z, Jia P, Sharma R, Zayats R, Viana SM, Shan L, Barral A, Boaventura VS, Murooka TT, Soussi-Gounni A, de Oliveira CI, Uzonna JE (2020). Cell Reports. 33(11):108513.
 
  • Koh WH, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J and Murooka TT. HIV-captured DCs regulate T cell migration and cell-cell contact dynamics to enhance viral spread. iScience. Aug 31; 23(8):101427.


2019
  • Lopez P, Koh WH, Hnatiuk R and Murooka TT. HIV infection stabilizes macrophage-T cell interactions to promote cell-cell HIV spread. Journal of Virology. Aug 28;93(18).
          * Editor's spotlight: https://jvi-asm-org.uml.idm.oclc.org/content/93/18/e01136-19


  • Usmani SM*, Murooka TT*, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD and Mempel TR. HIV-1 balances the fitness costs and benefits of disrupting the host cell actin cytoskeleton early after mucosal transmission. Cell Host Microbe. Jan 9;25(1).
        *co-first authorship

2018 
  • Ali AY, Wu X, Eissa N, Hou S, Ghia JE, Murooka TT, Banerji V, Johnston JB, Lin F, Gibson SB and Marshall AJ. Distinct roles of phosphoinositide 3-kinases gamma and delta in malignant B cell migration. Leukemia. Sept;32(9).
 
  • Pizzagalli Du, Farsakoglu Y, Palomino-Segura M, Palladino E, Sintes J, Marangoni F, Mempel TR, Koh WH, Murooka TT, Thelen F, Stein JV, Pozzi G, Thelen M, Krause R and Gonzalez SF.  Nature Scientific Data. July 17;5.


2017
  • Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR and Luster AD. Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex-induced arthritis. Science Immunology. Jan:2(7)
 
  • Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR and Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. Apr 6;2(7).


2016
  • Benechet AP, Menon M, Xu D, Samji T, Maher L, Murooka TT, Mempel TR, Sheridan BS, Lemoine FM and Khanna KM. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection.  Proc Natl Acad Sci. Feb 23;113(8):2182-7
 
  • Sharaf R, Mempel TR and Murooka TT.  Visualizing the behavior of HIV-infected T cells in vivo using multiphoton intravital microscopy.  Methods Mol. Biol. 1354:189-201

2015
  • Symeonides M, Murooka TT, Bellfy LN, Roy NH, Mempel TR and Thali M. HIV-1-induced small T cells syncytia can transfer virus particles to target cells through transient contacts.  Viruses. Dec 12;7(12):6590-603
 
  • Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, Shultz LD, Mempel TR, Bjorkman PJ, Kumar P and Mothes W.  Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.  Science. Oct 1[Epub ahead of print].
 
  • Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V and Glimcher LH.  Nature Communications. June 25;6:7562
 
  • Murooka TT, Radwa S and Mempel TR.  Large syncytia in lymph nodes induced by CCR5-tropic HIV-1.  AIDS and Human Retroviruses. 31(5)471-472.


2014
  • Fackler OT, Murooka TT, Imle A and Mempel TR.  Adding new dimensions: towards an integrative understanding of HIV-1 spread.  Nat. Rev. Microbiol. 12(8):563-74.
 
  • Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK and Addo MM.  HIV-1 infection impairs regulatory T cell suppressive capacity on a per-cell basis.  J. Infect. Dis. 210(6):899-903.


2013
  • Murooka TT and Mempel TR. Intravital microscopy in BLT humanized mice to study cellular dynamics in HIV infection.  J. Infect Dis. 208 Suppl 2:S137-44
 
  • Marangoni F, Murooka TT, Manzo T, Kim EY, Carrizosa E, Elpek NM and Mempel TR. NFAT memory enables signal integration in T cells during serial Interactions with antigen presenting cells.  Immunity.  38(2): 237-49


2012
  • Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD and Mempel TR. HIV-infected T cells are migratory vehicles for viral dissemination.  Nature. 490(7419):283-7
 
  • Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR and Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity. 14;37(6): 1091-1
 
  • Rahbar R, Rogers E, Murooka T, Kislinger T and Fish EN. Glomulin: a permissivity factor for vaccinia virus infection.  J. Interferon Cytokine Res. 32(3): 127-37
 
  • Murooka TT and Mempel T.R.  Multiphoton Intravital Microscopy to Study Lymphocyte Motility in Lymph Nodes.  Methods Mol. Biol. 757:247-57.


2010
  • Galligan CL, Pennell L, Murooka T, Baig E, Majchrzak-Kita B, Rahbar R and Fish EN.  Interferon-beta is a key regulator of proinflammatory events in experimental autoimmune encephalomyelitis. Mult. Scler. 16(12):1458-73.


2009
  • Murooka TT, Rahbar R and Fish EN. CCL5 promotes proliferation of MCF-7 cells through mTOR-dependent mRNA translation. Biochem. Biophys. Res. Commun. 387, 381-386.
 
  • Rahbar R, Murooka TT and Fish EN. Role for CCR5 in dissemination of vaccinia virus in vivo. J. Virol. 83, 2226-2236.


2008
  • Murooka TT, Rahbar R, Platanias LC and Fish EN.  CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1.  Blood.  111, 4892-4901.


2006
  • Rahbar R, Murooka TT, Hinek AA, Galligan CL, Sassano A, Yu C, Srivastava K, Platanias LC and Fish EN.  Vaccinia virus activation of CCR5 invokes tyrosine phosphorylation signaling events that support virus replication.  J. Virol. 80, 7245-7259.
 
  • Galligan CL, Murooka TT, Rahbar R, Baig E, Majchrzak-Kita B and Fish EN.  Interferons and viruses: signaling for supremacy.  Immunol Res. 35, 27-40.
 
  • Murooka TT, Wong MM, Rahbar R, Majchrzak-Kita B, Proudfoot AE and Fish EN.  CCL5-CCR5 mediated Apoptosis in T cells: Requirement for Glycosaminoglycan Binding and CCL5 Aggregation.  J. Biol. Chem. 281, 25184-25194.


2005
  • Murooka TT, Ward SE and Fish EN. Chemokines and cancer. Cancer Treat. Res. 126, 15-44.